The Inhibitory Effect of siRNAs on The High Glucose-Induced Overexpression of TGF-β1 in Mesangial Cells

Diabetic nephropathy is characterized by an expansion of the glomerular mesangium, caused by mesangial cell proliferation and an excessive accumulation of extracellar matrix (ECM) proteins, which eventually leading to glomerulosclerosis. TGF-β1 was found to play an important role in the accumulation...

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Bibliographic Details
Main Authors: Noh, Hey-Jeong, Kim, Hyun-Chul, Lee, Sang-Sook, Kang, Yu-Na, Chae, Young-Mi, Park, Kwan-Kyu
Format: Artigo
Language:Inglês
Published: The Korean Academy of Medical Sciences 2006
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2729946/
https://ncbi.nlm.nih.gov/pubmed/16778384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3346/jkms.2006.21.3.430
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