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Engineering and Expression of a Chimeric Transferrin Receptor Monoclonal Antibody for Blood–Brain Barrier Delivery in the Mouse
Protein therapeutics may be delivered across the blood–brain barrier (BBB) by genetic fusion to a BBB molecular Trojan horse. The latter is an endogenous peptide or a peptidomimetic monoclonal antibody (MAb) against a BBB receptor, such as the insulin receptor or the transferrin receptor (TfR). Fusi...
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| 主要な著者: | , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2009
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2729652/ https://ncbi.nlm.nih.gov/pubmed/18942151 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bit.22135 |
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