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MBD4 and MLH1 are required for apoptotic induction in xDNMT1-depleted embryos
Loss of the of the maintenance methyltransferase xDNMT1 during Xenopus development results in premature transcription and activation of a p53-dependent apoptotic program that accounts for embryo lethality. Here, we show that activation of the apoptotic response is signalled through the methyl-CpG bi...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Company of Biologists
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2729342/ https://ncbi.nlm.nih.gov/pubmed/19502488 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.032227 |
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