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Loss of the maintenance methyltransferase, xDnmt1, induces apoptosis in Xenopus embryos
DNA methylation is necessary for normal embryogenesis in animals. Here we show that loss of the maintenance methyltransferase, xDnmt1p, triggers an apoptotic response during Xenopus development, which accounts for the loss of specific cell populations in hypomethylated embryos. Hypomethylation-induc...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2001
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC125419/ https://ncbi.nlm.nih.gov/pubmed/11296229 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/20.8.1963 |
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