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SYNTHESIS, CHARACTERIZATION, AND IN VITRO ASSAY OF FOLIC ACID CONJUGATES OF 3′-AZIDO-3′-DEOXYTHYMIDINE (AZT): TOWARD TARGETED AZT BASED ANTICANCER THERAPEUTICS

Conjugates of three components namely folic acid, poly(ethylene glycol) and 3′-azido-3′-deoxythymidine (AZT) are presented. Folate-PEG units were coupled to AZT to facilitate delivery of the nucleoside into the cell. A convenient separation of the polydisperse PEGylated-folic acid regioisomers produ...

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書誌詳細
主要な著者: Vortherms, Anthony R., Doyle, Robert P., Gao, Dayuan, Debrah, Olivia, Sinko, Patrick J.
フォーマット: Artigo
言語:Inglês
出版事項: 2008
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2729114/
https://ncbi.nlm.nih.gov/pubmed/18205071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15257770701795946
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