Effects of Point Mutations in Plasmodium falciparum Dihydrofolate Reductase and Dihydropterate Synthase Genes on Clinical Outcomes and In Vitro Susceptibility to Sulfadoxine and Pyrimethamine

BACKGROUND: Sulfadoxine-pyrimethamine was a common first line drug therapy to treat uncomplicated falciparum malaria, but increasing therapeutic failures associated with the development of significant levels of resistance worldwide has prompted change to alternative treatment regimes in many nationa...

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Détails bibliographiques
Auteurs principaux: Bacon, David J., Tang, Doug, Salas, Carola, Roncal, Norma, Lucas, Carmen, Gerena, Lucia, Tapia, Lorena, Llanos-Cuentas, A. Alejandro, Garcia, Coralith, Solari, Lelv, Kyle, Dennis, Magill, Alan J.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2009
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2728505/
https://ncbi.nlm.nih.gov/pubmed/19707564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0006762
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