Molecular monitoring of the Leu-164 mutation of dihydrofolate reductase in a highly sulfadoxine/pyrimethamine-resistant area in Africa

The selection of point mutation at codon 164 (from isoleucine to leucine) of the dihydrofolate reductase (DHFR) enzyme in Plasmodium falciparum is associated with high sulfadoxine /pyrimethamine (SP) resistance. Using the yeast expression system that allows the detection of dhfr allele present at lo...

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Detalhes bibliográficos
Main Authors: Ochong, Edwin, Nzila, Alexis, Kimani, Serah, Kokwaro, Gilbert, Mutabingwa, Theonest, Watkins, William, Marsh, Kevin
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2003
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC317348/
https://ncbi.nlm.nih.gov/pubmed/14675491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2875-2-46
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