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Conversion of MDCK cell line to suspension culture by transfecting with human siat7e gene and its application for influenza virus production

MDCK cells are currently being considered as an alternative to embryonated eggs for influenza virus propagation and hemagglutinin (HA) production intended for vaccine manufacturing. MDCK cells were found suitable for the virus production but their inability to grow in suspension burdens the process...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Chu, Chia, Lugovtsev, Vladimir, Golding, Hana, Betenbaugh, Michael, Shiloach, Joseph
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2009
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2728112/
https://ncbi.nlm.nih.gov/pubmed/19706449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0905912106
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