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Human neuroblastoma cells rapidly enter cell cycle arrest and apoptosis following exposure to C-28 derivatives of the synthetic triterpenoid CDDO

Synthetic triterpenoids, such as 2-cyano-3,12-dioxoolean-1, 9-dien-28-oic acid (CDDO) and its derivatives, are an extremely potent class of new anti-cancer therapeutic agents, characterized by high anti-tumor potency and low toxicity to normal tissues. This report is the first to investigate the eff...

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Bibliografiske detaljer
Main Authors: Alabran, Jennifer L., Cheuk, Adam, Liby, Karen, Sporn, Michael, Khan, Javed, Letterio, John, Leskov, Konstantin S.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2727860/
https://ncbi.nlm.nih.gov/pubmed/18277094
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