The Taccalonolides: Microtubule Stabilizers that Circumvent Clinically Relevant Taxane Resistance Mechanisms

The taccalonolides are a class of structurally and mechanistically distinct microtubule-stabilizing agents isolated from Tacca chantrieri. A crucial feature of the taxane family of microtubule stabilizers is their susceptibility to cellular resistance mechanisms including overexpression of P-glycopr...

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Bibliografiske detaljer
Main Authors: Risinger, April L., Jackson, Evelyn M., Polin, Lisa A., Helms, Gregory L., LeBoeuf, Desiree A., Joe, Patrick A., Hopper-Borge, Elizabeth, Ludueña, Richard F., Kruh, Gary D., Mooberry, Susan L.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2727482/
https://ncbi.nlm.nih.gov/pubmed/18974132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-2037
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