D-(+)-iso-Methanocarbathymidine: a high affinity substrate for herpes simplex virus 1 thymidine kinase

The stereoselective syntheses of the (+)-D and (−)-L enantiomers of racemic iso-methanocarbathymidine (iso-MCT) was achieved through two independent linear approaches that converged on two antipodal enantiomers, common to a key precursor utilized in the synthesis of racemic iso-MCT. In this study we...

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Bibliographic Details
Main Authors: Comin, Maria J., Vu, B. Christie, Boyer, Paul L., Liao, Chenzhong, Hughes, Stephen H., Marquez, Victor E.
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2727455/
https://ncbi.nlm.nih.gov/pubmed/18399509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.200800027
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