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The Role of Herpes Simplex Virus-1 Thymidine Kinase Alanine 168 in Substrate Specificity

Herpes simplex virus type 1 (HSV) thymidine kinase (TK) has been widely used in suicide gene therapy for the treatment of cancer due to its broad substrate specificity and the inability of the endogenous human TK to phosphorylate guanosine analogs such as ganciclovir (GCV). The basis of suicide gene...

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Detaylı Bibliyografya
Asıl Yazarlar: Willmon, Candice L, Sussman, Django, Black, Margaret E
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Bentham Open 2008
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2570551/
https://ncbi.nlm.nih.gov/pubmed/18949076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2174/1874091X00802010060
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