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The Role of Herpes Simplex Virus-1 Thymidine Kinase Alanine 168 in Substrate Specificity
Herpes simplex virus type 1 (HSV) thymidine kinase (TK) has been widely used in suicide gene therapy for the treatment of cancer due to its broad substrate specificity and the inability of the endogenous human TK to phosphorylate guanosine analogs such as ganciclovir (GCV). The basis of suicide gene...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Bentham Open
2008
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2570551/ https://ncbi.nlm.nih.gov/pubmed/18949076 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2174/1874091X00802010060 |
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