Ocular Coloboma and Dorsoventral Neuroretinal Patterning Defects in Lrp6 Mutant Eyes

Coloboma, an ocular birth defect seen in humans and other species, is caused by incomplete closure of the optic fissure. Here, we demonstrate that genetic deletion of Lrp6, a bottleneck coreceptor in the canonical Wnt signaling pathway, results in ocular coloboma and neuroretinal patterning defects...

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Main Authors: Zhou, Cheng-Ji, Molotkov, Andrei, Song, Lanying, Li, Yunhong, Pleasure, David E., Pleasure, Samuel J., Wang, Ya-Zhou
Format: Artigo
Jezik:Inglês
Izdano: 2008
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2727282/
https://ncbi.nlm.nih.gov/pubmed/18985738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/dvdy.21770
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