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Ocular Coloboma and Dorsoventral Neuroretinal Patterning Defects in Lrp6 Mutant Eyes
Coloboma, an ocular birth defect seen in humans and other species, is caused by incomplete closure of the optic fissure. Here, we demonstrate that genetic deletion of Lrp6, a bottleneck coreceptor in the canonical Wnt signaling pathway, results in ocular coloboma and neuroretinal patterning defects...
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| Main Authors: | , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2008
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2727282/ https://ncbi.nlm.nih.gov/pubmed/18985738 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/dvdy.21770 |
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