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Renal fibrosis is attenuated by targeted disruption of K(Ca)3.1 potassium channels

Proliferation of interstitial fibroblasts is a hallmark of progressive renal fibrosis commonly resulting in chronic kidney failure. The intermediate-conductance Ca(2+)-activated K(+) channel (K(Ca)3.1) has been proposed to promote mitogenesis in several cell types and contribute to disease states ch...

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Hlavní autoři: Grgic, Ivica, Kiss, Eva, Kaistha, Brajesh P., Busch, Christoph, Kloss, Michael, Sautter, Julia, Müller, Anja, Kaistha, Anuradha, Schmidt, Claudia, Raman, Girija, Wulff, Heike, Strutz, Frank, Gröne, Hermann-Josef, Köhler, Ralf, Hoyer, Joachim
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2726862/
https://ncbi.nlm.nih.gov/pubmed/19706538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0903458106
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