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Endothelial Ca(2+)-activated K(+) channels in normal and impaired EDHF–dilator responses – relevance to cardiovascular pathologies and drug discovery

The arterial endothelium critically contributes to blood pressure control by releasing vasodilating autacoids such as nitric oxide, prostacyclin and a third factor or pathway termed ‘endothelium-derived hyperpolarizing factor’ (EDHF). The nature of EDHF and EDHF-signalling pathways is not fully unde...

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Autori principali: Grgic, Ivica, Kaistha, Brajesh P, Hoyer, Joachim, Köhler, Ralf
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Publishing Ltd 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2707963/
https://ncbi.nlm.nih.gov/pubmed/19302590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2009.00132.x
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