Selective blockade of endothelial Ca(2+)-activated small- and intermediate-conductance K(+)-channels suppresses EDHF-mediated vasodilation

1. Activation of Ca(2+)-activated K(+)-channels (K(Ca)) has been suggested to play a key role in endothelium-derived hyperpolarizing factor (EDHF)-mediated vasodilation. However, due to the low selectivity of commonly used K(Ca)-channel blockers it is still elusive which endothelial K(Ca)-subtypes m...

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Detalhes bibliográficos
Main Authors: Eichler, Ines, Wibawa, Judith, Grgic, Ivica, Knorr, Andrea, Brakemeier, Susanne, Pries, Axel R, Hoyer, Joachim, Köhler, Ralf
Formato: Artigo
Idioma:Inglês
Publicado em: 2003
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Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1573692/
https://ncbi.nlm.nih.gov/pubmed/12598413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0705075
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