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Inhibitory effects of persistent apoptotic cells on monoclonal antibody production in vitro: Simple removal of non-viable cells improves antibody productivity by hybridoma cells in culture

Cells undergoing apoptosis in vivo are rapidly detected and cleared by phagocytes. Swift recognition and removal of apoptotic cells is important for normal tissue homeostasis and failure in the underlying clearance mechanisms has pathological consequences associated with inflammatory and auto-immune...

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Hlavní autoři: Gregory, Christopher D, Pound, John D, Devitt, Andrew, Wilson-Jones, Megan, Ray, Parthasarathi, Murray, Ruth J
Médium: Artigo
Jazyk:Inglês
Vydáno: Landes Bioscience 2009
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2726608/
https://ncbi.nlm.nih.gov/pubmed/20068393
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