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Effects of CO2 and osmolality on hybridoma cells: growth, metabolism and monoclonal antibody production
CO2 partial pressure (pCO2) in industrial cell culture reactors may reach 150–200 mm Hg, which can significantly inhibit cell growth and recombinant protein production. Due to equilibrium with bicarbonate, increased pCO2 at constant pH results in a proportional increase in osmolality. Hybridoma AB2-...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Kluwer Academic Publishers
1998
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3449846/ https://ncbi.nlm.nih.gov/pubmed/19003422 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1023/A:1008010605287 |
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