Leptin Enhances Synthesis of Proinflammatory Mediators in Human Osteoarthritic Cartilage—Mediator Role of NO in Leptin-Induced PGE(2), IL-6, and IL-8 Production

Obesity is an important risk factor for osteoarthritis (OA) in weight-bearing joints, but also in hand joints, pointing to an obesity-related metabolic factor that influences on the pathogenesis of OA. Leptin is an adipokine regulating energy balance, and it has recently been related also to arthrit...

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Autori principali: Vuolteenaho, Katriina, Koskinen, Anna, Kukkonen, Meiju, Nieminen, Riina, Päivärinta, Unto, Moilanen, Teemu, Moilanen, Eeva
Natura: Artigo
Lingua:Inglês
Pubblicazione: Hindawi Publishing Corporation 2009
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2726438/
https://ncbi.nlm.nih.gov/pubmed/19688109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2009/345838
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