Atomistic View of the Conformational Activation of Src Kinase Using the String Method with Swarms-of-Trajectories

The inactive-to-active conformational transition of the catalytic domain of human c-Src tyrosine kinase is characterized using the string method with swarms-of-trajectories with all-atom explicit solvent molecular dynamics simulations. The activation process occurs in two main steps in which the act...

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Hlavní autoři: Gan, Wenxun, Yang, Sichun, Roux, Benoît
Médium: Artigo
Jazyk:Inglês
Vydáno: The Biophysical Society 2009
Témata:
Biophysical Letter
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2726321/
https://ncbi.nlm.nih.gov/pubmed/19686639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2009.06.016
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