ADAMTS1 and MMP1 proteolytically engage EGF-like ligands in an osteolytic signaling cascade for bone metastasis

Bone metastasis is mediated by complex interactions between tumor cells and resident stromal cells in the bone microenvironment. The functions of metalloproteinases in organ-specific metastasis remain poorly defined despite their well-appreciated role in matrix degradation and tumor invasion. Here,...

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Bibliografiske detaljer
Main Authors: Lu, Xin, Wang, Qiongqing, Hu, Guohong, Van Poznak, Catherine, Fleisher, Martin, Reiss, Michael, Massagué, Joan, Kang, Yibin
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2009
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2725946/
https://ncbi.nlm.nih.gov/pubmed/19608765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1824809
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