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Id1 Attenuates Notch Signaling and Impairs T-Cell Commitment by Elevating Deltex1 Expression
Complete inhibition of E protein transcription factors by Id1 blocks the developmental transition of CD4/CD8 double-negative 1 (DN1; CD44(+) CD25(−)) thymocytes to the DN2 (CD44(+) CD25(+)) stage. To understand the underlying mechanisms, we observed that mRNA levels of Deltex1, as well as Deltex4, w...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology (ASM)
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2725715/ https://ncbi.nlm.nih.gov/pubmed/19564409 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00119-09 |
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