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Id1 Attenuates Notch Signaling and Impairs T-Cell Commitment by Elevating Deltex1 Expression

Complete inhibition of E protein transcription factors by Id1 blocks the developmental transition of CD4/CD8 double-negative 1 (DN1; CD44(+) CD25(−)) thymocytes to the DN2 (CD44(+) CD25(+)) stage. To understand the underlying mechanisms, we observed that mRNA levels of Deltex1, as well as Deltex4, w...

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Bibliografske podrobnosti
Main Authors: Wang, Hong-Cheng, Perry, S. Scott, Sun, Xiao-Hong
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2009
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2725715/
https://ncbi.nlm.nih.gov/pubmed/19564409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00119-09
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