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The role of amphiphilicity and negative charge in glycoprotein 41 interactions in the hydrophobic pocket

The hydrophobic pocket within the coiled coil domain of HIV-1 gp41 is considered to be a hotspot suitable for small molecule intervention of fusion, although so far it has yielded only μM inhibitors. Previous peptide studies have identified specific hydrophobic interactions and a Lys-Asp salt bridge...

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Sonraí Bibleagrafaíochta
Main Authors: Gochin, Miriam, Cai, Lifeng
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2009
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2724993/
https://ncbi.nlm.nih.gov/pubmed/19534533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm900190q
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