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The protein tyrosine phosphatase SHP-2 is required for EGFRvIII oncogenic transformation in human glioblastoma cells

Oncogenic EGFRvIII is a naturally occurring oncoprotein and is expressed in about 40–50% of human glioblastomas, particular those that arise de novo. To understand the molecular mechanisms by which this oncoprotein alters transforming phenotypes, and since our previous work indicated that SHP-2 prot...

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Bibliografski detalji
Glavni autori: Zhan, Yi, Counelis, George J., O’Rourke, Donald M.
Format: Artigo
Jezik:Inglês
Izdano: 2009
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2724964/
https://ncbi.nlm.nih.gov/pubmed/19427850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yexcr.2009.05.001
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