Palmitate increases sphingosine-1-phosphate in C2C12 myotubes via upregulation of sphingosine kinase message and activity

Studies in skeletal muscle demonstrate that elevation of plasma FFAs increases the sphingolipid ceramide. We aimed to determine the impact of FFA oversupply on total sphingolipid profiles in a skeletal muscle model. C2C12 myotubes were treated with palmitate (PAL). Lipidomics analysis revealed pleio...

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Autors principals: Hu, Wei, Bielawski, Jacek, Samad, Fahumiya, Merrill, Alfred H., Cowart, L. Ashley
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Biochemistry and Molecular Biology 2009
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2724779/
https://ncbi.nlm.nih.gov/pubmed/19369694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M800635-JLR200
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