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New synthetic strategies for the stereocontrolled synthesis of substituted “skipped” diepoxides

This report describes a number of new synthetic approaches towards methyl-substituted mono- and diepoxy alcohols that serve as substrates for endo-selective epoxide-opening cascades. The key transformations involve the manipulation of alkynes. Highlighted are the directed methylmetalation of bishomo...

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Detalhes bibliográficos
Main Authors: Morten, Christopher J., Jamison, Timothy F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2724682/
https://ncbi.nlm.nih.gov/pubmed/20161178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tet.2009.05.074
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