Physiologic Deformational Loading Does Not Counteract the Catabolic Effects of Interleukin-1 in Long-Term Culture of Chondrocyte-seeded Agarose Constructs

An interplay of mechanical and chemical factors is integral to cartilage maintenance and/or degeneration. Interleukin-1 (IL-1) is a pro-inflammatory cytokine that is present at elevated concentrations in osteoarthritic joints and initiates the rapid degradation of cartilage when cultured in vitro. S...

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Bibliographische Detailangaben
Hauptverfasser: Lima, Eric G., Tan, Andrea R., Tai, Timon, Bian, Liming, Ateshian, Gerard A., Cook, James L., Hung, Clark T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2724593/
https://ncbi.nlm.nih.gov/pubmed/18823628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbiomech.2008.06.015
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