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Cardiac alternans induced by fibroblast-myocyte coupling: mechanistic insights from computational models

Recent experimental studies have shown that fibroblasts can electrotonically couple to myocytes via gap junctions. In this study, we investigated how this coupling affects action potential and intracellular calcium (Ca(i)) cycling dynamics in simulated fibroblast-myocyte pairs and in two-dimensional...

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Detalles Bibliográficos
Main Authors: Xie, Yuanfang, Garfinkel, Alan, Weiss, James N., Qu, Zhilin
Formato: Artigo
Idioma:Inglês
Publicado: American Physiological Society 2009
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2724208/
https://ncbi.nlm.nih.gov/pubmed/19482965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00341.2009
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