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T-tubule Disruption Promotes Calcium Alternans in Failing Ventricular Myocytes: Mechanistic Insights from Computational Modeling

In heart failure (HF), T-tubule (TT) disruption contributes to dyssynchronous calcium (Ca) release and impaired contraction, but its role in arrhythmogenesis remains unclear. In this study, we investigate the mechanisms of TT disruption and other HF remodeling factors on Ca alternans in ventricular...

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Bibliographic Details
Published in:J Mol Cell Cardiol
Main Authors: Nivala, Michael, Song, Zhen, Weiss, James N., Qu, Zhilin
Format: Artigo
Language:Inglês
Published: 2014
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4323351/
https://ncbi.nlm.nih.gov/pubmed/25450613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2014.10.018
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