The Structure of OMCI, a Novel Lipocalin Inhibitor of the Complement System

The complement (C) system is a potent innate immune defence system against parasites. We have recently characterised and expressed OmCI, a 16 kDa protein derived from the soft tick Ornithodoros moubata that specifically binds C5, thereby preventing C activation. The structure of recombinant OmCI det...

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Main Authors: Roversi, Pietro, Lissina, Olga, Johnson, Steven, Ahmat, Nurfilza, Paesen, Guido C., Ploss, Kerstin, Boland, Wilhelm, Nunn, Miles A., Lea, Susan M.
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2007
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2724154/
https://ncbi.nlm.nih.gov/pubmed/17445829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2007.03.064
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