Dynamics of β-cell turnover: evidence for β-cell turnover and regeneration from sources of β-cells other than β-cell replication in the HIP rat

Type 2 diabetes is characterized by hyperglycemia, a deficit in β-cells, increased β-cell apoptosis, and islet amyloid derived from islet amyloid polypeptide (IAPP). These characteristics are recapitulated in the human IAPP transgenic (HIP) rat. We developed a mathematical model to quantify β-cell t...

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Detalhes bibliográficos
Main Authors: Manesso, Erica, Toffolo, Gianna M., Saisho, Yoshifumi, Butler, Alexandra E., Matveyenko, Aleksey V., Cobelli, Claudio, Butler, Peter C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2009
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2724115/
https://ncbi.nlm.nih.gov/pubmed/19470833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00284.2009
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