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Altered thymic selection and increased autoimmunity caused by ectopic expression of DRAK2 during T cell development

Negative regulation of T cell receptor (TCR) signaling is an important mechanism enforcing immunological self-tolerance to prevent inappropriate activation of T cells and thus the development of autoimmune diseases. The lymphoid-restricted serine/threonine kinase DAP-related apoptotic kinase-2 (DRAK...

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Autors principals: Gatzka, Martina, Newton, Ryan H., Walsh, Craig M.
Format: Artigo
Idioma:Inglês
Publicat: 2009
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2724075/
https://ncbi.nlm.nih.gov/pubmed/19542440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0803530
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