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Topology is the Principal Determinant in the Folding of a Complex All-alpha Greek Key Death Domain from Human FADD

In order to elucidate the relative importance of secondary structure and topology in determining folding mechanism, we have carried out a phi-value analysis of the death domain (DD) from human FADD. FADD DD is a 100 amino acid domain consisting of six anti-parallel alpha helices arranged in a Greek...

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Hlavní autoři: Steward, Annette, McDowell, Gary S., Clarke, Jane
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2724026/
https://ncbi.nlm.nih.gov/pubmed/19362094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2009.04.004
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