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Connexin 30 Deficiency Impairs Renal Tubular ATP Release and Pressure Natriuresis

In the renal tubule, ATP is an important regulator of salt and water reabsorption, but the mechanism of ATP release is unknown. Several connexin (Cx) isoforms form mechanosensitive, ATP-permeable hemichannels. We localized Cx30 to the nonjunctional apical membrane of cells in the distal nephron and...

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Bibliographische Detailangaben
Hauptverfasser: Sipos, Arnold, Vargas, Sarah L., Toma, Ildikó, Hanner, Fiona, Willecke, Klaus, Peti-Peterdi, János
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Nephrology 2009
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2723976/
https://ncbi.nlm.nih.gov/pubmed/19478095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2008101099
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