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Synthesis of a natural product-inspired eight-membered ring lactam library via ring-closing metathesis

We have prepared a novel speculative eight-membered lactam demonstration library based on the skeletal structure of the potent antitumor marine natural product octalactin A. The basic scaffold was readily constructed in a convergent fashion via ring-closing metathesis chemistry from the correspondin...

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Библиографические подробности
Главные авторы: Brown, Neil, Xie, Baohan, Markina, Nataliya, VanderVelde, David, Perchellet, Jean-Pierre H., Perchellet, Elisabeth M., Crow, Kyle R., Buszek, Keith R.
Формат: Artigo
Язык:Inglês
Опубликовано: 2008
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2723794/
https://ncbi.nlm.nih.gov/pubmed/18703334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2008.07.074
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