Systemic neutralizing antibodies induced by long interval mucosally primed systemically boosted immunization correlate with protection from mucosal SHIV challenge

Immune correlates of vaccine protection from HIV-1 infection would provide important milestones to guide HIV-1 vaccine development. In a proof of concept study using mucosal priming and systemic boosting, the titer of neutralizing antibodies in sera were found to correlate with protection of mucosal...

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Main Authors: Bogers, Willy M.J.M., Davis, David, Baak, Ilona, Kan, Elaine, Hofman, Sam, Sun, Yide, Mortier, Daniella, Lian, Ying, Oostermeijer, Herman, Fagrouch, Zahra, Dubbes, Rob, Maas, Martin van der, Mooij, Petra, Koopman, Gerrit, Verschoor, Ernst, Langedijk, Johannes P.M., Zhao, Jun, Brocca-Cofano, Egidio, Robert-Guroff, Marjorie, Srivastava, Indresh, Barnett, Susan, Heeney, Jonathan L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2723753/
https://ncbi.nlm.nih.gov/pubmed/18947849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2008.09.016
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