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α,β-Difluoromethylene deoxynucleoside 5’-triphosphates: a convenient synthesis of useful probes for DNA polymerase β structure and function

[Image: see text] α,β-Difluoromethylene deoxynucleoside 5’-triphosphates (dNTPs, N = A or C) are advantageously obtained via phosphorylation of corresponding dNDP analogues using catalytic ATP, PEP, nucleoside diphosphate kinase (NDPK) and pyruvate kinase (PK). DNA pol β K(d) values for the α,β-CF(2...

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Bibliografiske detaljer
Main Authors: Upton, Thomas G., Kashemirov, Boris A., McKenna, Charles E., Goodman, Myron F., Prakash, G. K. Surya, Kultyshev, Roman, Batra, Vinod K., Shock, David D., Pedersen, Lars C., Beard, William A., Wilson, Samuel H.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2722935/
https://ncbi.nlm.nih.gov/pubmed/19351147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol701755k
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