α,β-Difluoromethylene deoxynucleoside 5’-triphosphates: a convenient synthesis of useful probes for DNA polymerase β structure and function

[Image: see text] α,β-Difluoromethylene deoxynucleoside 5’-triphosphates (dNTPs, N = A or C) are advantageously obtained via phosphorylation of corresponding dNDP analogues using catalytic ATP, PEP, nucleoside diphosphate kinase (NDPK) and pyruvate kinase (PK). DNA pol β K(d) values for the α,β-CF(2...

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Detalhes bibliográficos
Main Authors: Upton, Thomas G., Kashemirov, Boris A., McKenna, Charles E., Goodman, Myron F., Prakash, G. K. Surya, Kultyshev, Roman, Batra, Vinod K., Shock, David D., Pedersen, Lars C., Beard, William A., Wilson, Samuel H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2722935/
https://ncbi.nlm.nih.gov/pubmed/19351147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol701755k
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