α,β-Difluoromethylene deoxynucleoside 5’-triphosphates: a convenient synthesis of useful probes for DNA polymerase β structure and function

[Image: see text] α,β-Difluoromethylene deoxynucleoside 5’-triphosphates (dNTPs, N = A or C) are advantageously obtained via phosphorylation of corresponding dNDP analogues using catalytic ATP, PEP, nucleoside diphosphate kinase (NDPK) and pyruvate kinase (PK). DNA pol β K(d) values for the α,β-CF(2...

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Autores principales: Upton, Thomas G., Kashemirov, Boris A., McKenna, Charles E., Goodman, Myron F., Prakash, G. K. Surya, Kultyshev, Roman, Batra, Vinod K., Shock, David D., Pedersen, Lars C., Beard, William A., Wilson, Samuel H.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2009
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2722935/
https://ncbi.nlm.nih.gov/pubmed/19351147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol701755k
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