GM-CSF INHIBITS BREAST CANCER GROWTH AND METASTASIS BY INVOKING AN ANTI-ANGIOGENIC PROGRAM IN TUMOR-EDUCATED MACROPHAGES

Tumor-educated macrophages facilitate tumor metastasis and angiogenesis. We discovered that GM-CSF blocked macrophages VEGF activity by producing soluble VEGF receptor-1 (sVEGFR-1) and determined the effect on tumor-associated macrophage behavior and tumor growth. We show GM-CSF treatment of murine...

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Detalhes bibliográficos
Main Authors: Eubank, Tim D., Roberts, Ryan D., Khan, Mahmood, Curry, Jennifer M., Nuovo, Gerard J., Kuppusamy, Periannan, Marsh, Clay B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2722508/
https://ncbi.nlm.nih.gov/pubmed/19223554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-1405
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