Simultaneous inactivation of Par-4 and PTEN in vivo leads to synergistic NF-κB activation and invasive prostate carcinoma

Prostate cancer is one of the most common neoplasias in men. The tumor suppressor Par-4 is an important negative regulator of the canonical NF-κB pathway and is highly expressed in prostate. Here we show that Par-4 expression is lost in a high percentage of human prostate carcinomas, and this occurs...

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Autori principali: Fernandez-Marcos, Pablo J., Abu-Baker, Shadi, Joshi, Jayashree, Galvez, Anita, Castilla, Elias A., Cañamero, Marta, Collado, Manuel, Saez, Carmen, Moreno-Bueno, Gema, Palacios, Jose, Leitges, Michael, Serrano, Manuel, Moscat, Jorge, Diaz-Meco, Maria T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2009
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2722271/
https://ncbi.nlm.nih.gov/pubmed/19470463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0813055106
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