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Genetic inactivation of Par4 results in hyperactivation of NF-κB and impairment of JNK and p38
The Par4 gene was first identified in prostate cells undergoing apoptosis after androgen withdrawal. PAR4 was subsequently shown to interact with, and inhibit, atypical protein kinase C isoforms, functioning as a negative regulator of the NF-κB pathway. This may explain its pro-apoptotic function in...
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| Asıl Yazarlar: | , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2003
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1315897/ https://ncbi.nlm.nih.gov/pubmed/12634851 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.embor.embor769 |
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