An activating mutation in the CSF3R gene induces a hereditary chronic neutrophilia

We identify an autosomal mutation in the CSF3R gene in a family with a chronic neutrophilia. This T617N mutation energetically favors dimerization of the granulocyte colony-stimulating factor (G-CSF) receptor transmembrane domain, and thus, strongly promotes constitutive activation of the receptor a...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Plo, Isabelle, Zhang, Yanyan, Le Couédic, Jean-Pierre, Nakatake, Mayuka, Boulet, Jean-Michel, Itaya, Miki, Smith, Steven O., Debili, Najet, Constantinescu, Stefan N., Vainchenker, William, Louache, Fawzia, de Botton, Stéphane
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2009
Fag:
Brief Definitive Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2722170/
https://ncbi.nlm.nih.gov/pubmed/19620628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20090693
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker