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Knocking-Down Cyclin A(2) by siRNA Suppresses Apoptosis and Switches Differentiation Pathways in K562 Cells upon Administration with Doxorubicin

Cyclin A(2) is critical for the initiation of DNA replication, transcription and cell cycle regulation. Cumulative evidences indicate that the deregulation of cyclin A(2) is tightly linked to the chromosomal instability, neoplastic transformation and tumor proliferation. Here we report that treatmen...

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Detalhes bibliográficos
Main Authors: Wang, Xiaohui, Song, Yujun, Ren, Jinsong, Qu, Xiaogang
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2721982/
https://ncbi.nlm.nih.gov/pubmed/19684852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0006665
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