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Synthesis and pharmacological characterization of [(125)I]MRS1898, a high-affinity, selective radioligand for the rat A(3) adenosine receptor

A known selective agonist of the A(3) adenosine receptors (AR), MRS1898 [(1′R,2′R,3′S,4′R,5′S)-4-{2-chloro-6-[(3-iodophenylmethyl)amino]purin-9-yl}-1-(methylaminocarbonyl)bicyclo[3.1.0]hexane-2,3-diol], was synthesized in radioactive form and characterized pharmacologically. This agonist ligand seri...

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Autors principals: Gao, Zhan-Guo, Teng, Bao, Wu, Haitao, Joshi, Bhalchandra V., Griffiths, Gary L., Jacobson, Kenneth A.
Format: Artigo
Idioma:Inglês
Publicat: Springer Netherlands 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2721771/
https://ncbi.nlm.nih.gov/pubmed/18528782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11302-008-9107-1
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