Nrf2- and PPARα-Mediated Regulation of Hepatic Mrp Transporters after Exposure to Perfluorooctanoic Acid and Perfluorodecanoic Acid

Perfluorooctanoic acid and perfluorodecanoic acid (PFDA) are commonly used as emulsifiers and surfactants in fluoropolymer manufacturing and are known peroxisome proliferator–activated receptor alpha (PPARα) agonists. PPARα activation induces β- and ω-oxidation enzymes such as Cyp4a14 and acyl-CoA o...

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Bibliografiske detaljer
Main Authors: Maher, Jonathan M., Aleksunes, Lauren M., Dieter, Matthew Z., Tanaka, Yuji, Peters, Jeffrey M., Manautou, Jose E., Klaassen, Curtis D.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2008
Fag:
Biotransformation and Toxicokinetics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2721675/
https://ncbi.nlm.nih.gov/pubmed/18757529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfn177
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