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Altered Disposition of Acetaminophen in Nrf2-null and Keap1-knockdown Mice
Acetaminophen (AA) is a widely used antipyretic drug that causes hepatotoxicity at high doses. Nuclear factor erythroid 2–related factor 2 (Nrf2) is a transcription factor that mitigates electrophilic stress from AA by inducing genes, such as NAD(P)H:quinone oxidoreductase 1 (Nqo1), multidrug resist...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Oxford University Press
2009
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2675638/ https://ncbi.nlm.nih.gov/pubmed/19246624 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfp047 |
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