Nrf2- and PPARα-Mediated Regulation of Hepatic Mrp Transporters after Exposure to Perfluorooctanoic Acid and Perfluorodecanoic Acid

Perfluorooctanoic acid and perfluorodecanoic acid (PFDA) are commonly used as emulsifiers and surfactants in fluoropolymer manufacturing and are known peroxisome proliferator–activated receptor alpha (PPARα) agonists. PPARα activation induces β- and ω-oxidation enzymes such as Cyp4a14 and acyl-CoA o...

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Hlavní autoři: Maher, Jonathan M., Aleksunes, Lauren M., Dieter, Matthew Z., Tanaka, Yuji, Peters, Jeffrey M., Manautou, Jose E., Klaassen, Curtis D.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2008
Témata:
Biotransformation and Toxicokinetics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2721675/
https://ncbi.nlm.nih.gov/pubmed/18757529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfn177
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