Role of GRP78/BiP Degradation and ER Stress in Deoxynivalenol-Induced Interleukin-6 Upregulation in the Macrophage

The trichothecene mycotoxin deoxynivalenol (DON) induces systemic expression of the interleukin-6 (IL-6) and other proinflammatory cytokines in the mouse. The purpose of this study was to test the hypothesis that DON triggers an endoplasmic reticulum (ER) stress response in murine macrophages capabl...

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Bibliographic Details
Main Authors: Shi, Yuhui, Porter, Katie, Parameswaran, Narayanan, Bae, Hee Kyong, Pestka, James J.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2009
Subjects:
Immunotoxicology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2721661/
https://ncbi.nlm.nih.gov/pubmed/19336499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfp060
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