Osteo-Chondroprogenitor–Specific Deletion of the Selenocysteine tRNA Gene, Trsp, Leads to Chondronecrosis and Abnormal Skeletal Development: A Putative Model for Kashin-Beck Disease

Kashin-Beck disease, a syndrome characterized by short stature, skeletal deformities, and arthropathy of multiple joints, is highly prevalent in specific regions of Asia. The disease has been postulated to result from a combination of different environmental factors, including contamination of barle...

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Bibliografiske detaljer
Main Authors: Downey, Charlene M., Horton, Chelsea R., Carlson, Bradley A., Parsons, Trish E., Hatfield, Dolph L., Hallgrímsson, Benedikt, Jirik, Frank R.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2009
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2721633/
https://ncbi.nlm.nih.gov/pubmed/19696890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1000616
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